What does 1 Thessalonians 5:25 mean?

Paul appeals to the Thessalonians as brothers to pray for him and his coworkers. Although he was an outstanding servant of God, Paul never considered himself to be beyond the need of prayer. Paul understood that he could not serve God adequately without God's help. In 2 Corinthians 3:5 he admitted his inadequacy but assured the Corinthians that God was his sufficiency. Like Paul, we need to solicit the prayers of our fellow believers, knowing that we can do nothing productive apart from the Lord's enabling (John 15:5).

Paul specifically asked the Christians at Rome to pray for three primary requests. First, that he would be delivered from those in Jerusalem who wanted to harm him. Second, that his service of delivering an offering to the persecuted Jewish Christians would be well received. Third, that God would allow him to visit the Christians at Rome (Romans 15:31–32).

Even Jesus prayed. The Gospels mention Jesus praying multiple times. John 17 records what is called His high priestly prayer in which He prayed for His followers.