What does 2 Timothy 4:22 mean?

Paul's final words in the New Testament offer much encouragement to Timothy and today's readers: "The Lord be with your spirit. Grace be with you." Jesus being "with your spirit" is also mentioned in the conclusions of three of Paul's other letters (Galatians 6:18; Philippians 4:23; Philemon 1:25). "Grace be with you" ended other Pauline letters as well (Colossians 4:18; 1 Timothy 6:21; Titus 3:15).

Many questions remain unanswered at the end of 2 Timothy. Did Timothy make it to Paul before his death? How and when did Paul die? When was Paul arrested and imprisoned in Rome? When was his "first defense"? What happened to Luke, Mark, Timothy, and others closely connected with Paul following this time? Though much is unknown, it is clear Paul ended his last letter fully focused on Christ, faithfully serving him until his end. His letters and life continue to inspire believers around the world today who seek to serve the Lord Jesus Christ.