What does Acts 14:6 mean?

Not long before, Paul and Barnabas had fled Pisidian Antioch when synagogue leaders convinced the civil Gentile leaders the two Jesus-followers were dangerous (Acts 13:50). Now, the apostles are driven out of Iconium, having learned those Jews and Gentiles who refused their message about Jesus are planning on stoning them (Acts 14:5). Lystra is a small town compared to the major trading centers of Pisidian Antioch and Iconium.

Lycaonia is a district in the large territory of Galatia which takes up the center of modern-day Asia Minor. Paul and Barnabas travel between Pisidian Antioch, Iconium, Lystra, and Derbe. All of these are in south Galatia. When Paul wrote his letter to the Galatians, it was likely passed around through the churches in these cities.

Lystra is a small town 20 miles south of Iconium and doesn't appear to have enough Jews to support a synagogue of its own. On Paul's second missionary journey, however, it is where he will meet his son in the faith, Timothy (Acts 16:1). Derbe is a larger city about 63 miles east and a bit south of Lystra. Right across the mountain range to the east is Paul's hometown of Tarsus. Later, Timothy and Gaius of Derbe will accompany Paul west to Macedonia and Greece (Acts 20:4). Paul revisits Lystra and Derbe on his second (Acts 16:6) and third (Acts 18:23) missionary journeys.