What does Genesis 26:22 mean?
Having moved some distance away from the main population of Gerar (Genesis 26:14–17), Isaac's men have dug two wells so far. In both cases, they were challenged by the local herdsmen over the rights to the water. Isaac named both wells to represent the disputes that came from them (Genesis 26:18–21). The first was called Esek, the second Sitnah, meaning "contention" and "quarrel," respectively. This choice seems to reflect a passive attitude on the part of Isaac, since he's clearly powerful enough to keep those wells by force, if he so chose.The third well, however, brings no dispute from the locals. Perhaps they gave up challenging Isaac once they realized he would just keep digging wells. Or, perhaps Isaac's family has moved far enough away that it's just not worth a challenge from the locals anymore, we don't know, but Isaac appears to be satisfied. He names this well Rehoboth, which means "broad places" or "room," and he gives credit to the Lord for providing it.
Specifically, Isaac notices that the Lord has made room for his enormous estate to settle in the region. Nothing would now stand in the way of the fruitful growth of all of his possessions.