What does Genesis 5:22 mean?

This verse is the first to break with the pattern seen so far. As usual, we are given the number of years that a man lived after fathering the son who would lead to Noah and his children. This time, though, we're told something about that man: Enoch "walked with God," a fact that will be repeated in the surprising verses to follow. In the Bible, the expression "walked with God" refers to someone who is obedient and devoted to the Lord, resulting in His favor. In Enoch's case, this was so vital a point that it's mentioned twice: both here and in verse 24.

This passage is primarily intended to explain the family tree from Adam to Noah, so there are few other details given. We really don't know much about Enoch. However, we do know that God chose to remove him from earth prior to his natural death. Enoch is the first of the men listed in this chapter whose story does not end with the phrase "and he died." This was probably an event similar to the end of Elijah's ministry, when he was taken bodily by God into heaven (2 Kings 2:9–12).