What does Isaiah 13:22 mean?
Looking ahead to what was then the future, Isaiah describes the end state of Babylon once the judgment of God has fallen. This sight is not pretty. The people of this once powerful and beautiful city will have been killed (Isaiah 13:12). The city itself will be destroyed. The once-glorious, luxurious city will be empty of people. Nobody will occupy it for generations, at the very least (Isaiah 13:20).Instead of the glory of man, the city will become home to wild beasts. Hyenas will make their laughing cry from the ruins of Babylon's once-great towers. Jackals will call out in public spaces. This is in addition to the goats, ostriches, and other howling creatures (Isaiah 13:21). It's an eerie, haunting scene of a once-urban place that has become inhospitable to people.
Isaiah concludes the prophecy by declaring that its fulfillment is not far off. The days of Babylon are numbered. This destruction did not take place during Isaiah's lifetime. Judah was still occupied with the Assyrian threat while the prophet lived. The Lord revealed through Isaiah what would eventually become of the powerful nation. Those that conquer will always be conquered. Empires rise and fall (Daniel 2:39–43), but the glory of the Lord is forever (Psalm 9:5–8).
The message to Israel in this oracle is clear: do not trust in kings and kingdoms or in the false gods of the nations. Trust in the Lord God. His might is absolute. And He is the only safe refuge (Isaiah 40:6–8).