What does Luke 22:41 mean?
Jesus and the disciples are in the garden of Gethsemane on the Mount of Olives (Luke 22:39; Mark 14:32). Jesus has asked the disciples to sit while He prays. He takes Peter, James, and John a little bit away and tells them, "My soul is very sorrowful, even to death; remain here, and watch with me" (Matthew 26:38). He also tells them, "Pray that you may not enter into temptation" (Luke 22:40).Now, He separates from them; the Greek can refer to an emotional distance as well as a geographic one, but they are close enough that they can hear Him. Jesus falls on His face and prays, "Father, if you are willing, remove this cup from me. Nevertheless, not my will, but yours, be done" (Luke 22:42; Matthew 26:39).
Earlier in His ministry, Jesus fell asleep in a boat in a raging storm. When the disciples woke Him up, He commented on their lack of faith. He could do so because He knew that in that moment, He was in His Father's will; nothing would happen to them. Then, He was safe (Mark 4:35–41).
Now, Jesus is in the Father's will and most certainly not safe (Luke 9:22). He knows that within hours He will be scourged and crucified. Even worse, He will carry the weight of the sins of the world. His earthly life is in grave danger, so He does the only thing He can: talk to His Father.