What does Luke 22:65 mean?

Luke's account of the abuses Jesus suffers during the illegal trail at the home of the high priest Caiaphas is mercifully short. The guards mock and beat Jesus. They blindfold Him, strike Him, and demand that He prophecy who was the culprit (Luke 22:63–64). It's difficult to say which is more painful. Probably it was not the beatings. Perhaps it was the fact that Judas, one of Jesus' closest friends, betrayed Him to men that want to kill Him (Luke 22:47–48), or that Peter , who so often acted as if he were the self-appointed leader of the Twelve, denied that he knew Jesus and then ran into the night (Luke 22:54–62). The greatest torture may be that the religious and civil leaders of the Jews are presently rejecting their Messiah. Jesus has admitted to being "the Christ, the Son of God." He has warned them that they will see Him sitting at God's right hand. The high priest's response is to dramatically tear his robes as if in mourning and declare Jesus' words blasphemous (Matthew 26:63–65).

A high priest should know better. He should know the Jewish Scriptures so well that when he looks at Jesus, the words of the prophets leap off the page and shout, "This is Him! This is the One you have waited for" (John 5:39–40)! The high priest should lead the Sanhedrin and then the people into worship of their God incarnate. Let the Romans crucify Him for other reasons, but let the Jews worship their God!

Jesus knows this can't happen. He told the disciples He must be arrested so that the prophets would be fulfilled (Matthew 26:56). The prophecy of the Suffering Servant must come true (Isaiah 52:13—53:12). Not just that He will be pierced, carry our griefs, and refuse to defend Himself; the entire prophecy will come true.

He was despised and rejected by men,
a man of sorrows and acquainted with grief;
and as one from whom men hide their faces
he was despised, and we esteemed him not. (Isaiah 53:3)