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Matthew 26:42
ESV Again, for the second time, he went away and prayed, "My Father, if this cannot pass unless I drink it, your will be done."
NIV He went away a second time and prayed, "My Father, if it is not possible for this cup to be taken away unless I drink it, may your will be done."
NASB He went away again a second time and prayed, saying, 'My Father, if this cup cannot pass away unless I drink from it, Your will be done.'
CSB Again, a second time, he went away and prayed, "My Father, if this cannot pass unless I drink it, your will be done."
NLT Then Jesus left them a second time and prayed, 'My Father! If this cup cannot be taken away unless I drink it, your will be done.'
KJV He went away again the second time, and prayed, saying, O my Father, if this cup may not pass away from me, except I drink it, thy will be done.
NKJV Again, a second time, He went away and prayed, saying, “O My Father, if this cup cannot pass away from Me unless I drink it, Your will be done.”

What does Matthew 26:42 mean?

Most of the disciples are sitting together some distance away from Jesus (Matthew 26:36). He has brought Peter, James, and John deeper into the garden at Gethsemane and has asked them to watch with Him (Matthew 26:37). Now for the second time, He has left them to walk about a stone's throw away (Luke 22:40) and pray in agony to God the Father (Matthew 26:38–39; Mark 14:34; Luke 22:44).

Jesus again emphasizes that He wants His Father's will to be done. His natural, human emotions are agonized over what He knows is coming (Hebrews 4:15). The reference to drinking connects to Jesus' previous prayer in verse 39, where He describes the coming judgment of and separation from God as a "cup." He knows the time has come to endure these things, and He is declaring His desire—His preference—not to do so to God the Father. He will trust His Father's decision.

Jesus, of course, has understood for a long time that His destiny was to die on the cross for the sins of humanity, to be raised back to life in a demonstration of the power of God. He has repeatedly told the disciples that His arrest, conviction, and execution were near (Matthew 16:21). It is likely this awareness of what will soon take place that drives Him to ask the Father whether it is possible to have it pass on from Him. He only makes the request, though, with the understanding that He will do absolutely anything the Father directs. God's will is primary, above and beyond His request.
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