What does Philippians 2:21 mean?

In contrast with Timothy's attitude, Paul notes the general nature of people as selfish. The idea of "interests" refers to their own desires or preferences. Few people truly choose the way of Jesus (Philippians 2:6–11) and live with humility toward others, even among believers in Jesus. In fact, Paul notes Timothy as unique among those with him, indicating that even many Christians live lives focused on personal interests. This echoes some of the sentiment Paul expressed in Philippians 1:15–18.

This verse also connects the interests of Jesus Christ with a concern for the Philippian believers, mentioned in verse 20. In this way, Paul reminds the reader that Jesus is very concerned about the situation of the Philippian believers. They were of great importance to the Lord and to Paul. Just as God the Father sent the one closest to Him by sending Jesus the Son, so too Paul sent the one closest to him, Timothy, one he refers to as a son (Philippians 2:22).