What does Philippians 4:21 mean?

This verse begins the conclusion to Paul's letter, consisting of the final three verses of Philippians. Paul's conclusion begins with a request to pass along greetings. Paul refers to all of the Philippian believers as "saints" here, as well as in the first verse of the letter (Philippians 1:1). In Philippians 4:22, he will add that all the saints with Paul, meaning all the Christian believers Paul was working with in Rome, send greetings to the Philippians. Unlike today's perception of saints as a special class of spiritual individuals, the New Testament portrays every true believer as a saint, a word meaning "holy one."

Paul adds greetings from the believers with him in Rome. The use of anthropoi indicates this group may consist of both "brothers and sisters" and is not specific only to men. The church in Rome was growing rapidly during this time, expanding even from the time Paul wrote the book of Romans, in about AD 56. Just six years later, it appears Paul has reached many more with the gospel.