What does Psalm 2:10 mean?

The psalmist, David (Acts 4:25), advises the kings to be wise, and he issues a warning to the rulers. It is unwise to oppose God considering His ability to execute His wrath on all who refuse to be warned. The idea of opposing God and defying His truth is laughable (Psalm 2:1–6). Those who oppose God and His Anointed One will face utter destruction (Psalm 2:7–9).

Even without the return of Messiah to rule the world (Revelation 19:11; 20:4), there are biblical examples of God humiliating those who arrogantly defy Him. Two Babylonian kings learned firsthand that God is not to be trifled with. In a display of his inflated ego, King Nebuchadnezzar erected a 90-foot-tall golden image on the plain of Dura. He commanded everyone to fall down at the sound of music and worship the image (Daniel 3:1–7). Later, he boasted about Babylon as a great city that he had built (Daniel 4:30). Such egotistical idolatry incurred God's wrath. God humbled Nebuchadnezzar by driving him from men to eat grass like an ox for seven years (Daniel 4:33–37). Sometime later, Nebuchadnezzar's grandson Belshazzar was King of Babylon, and he, too, was proud and idolatrous (Daniel 5:1–4). God responded to Belshazzar's wickedness by allowing the Medes and Persians to kill him and seize his kingdom (Daniel 5:30–31).

Acts 12:20–23 records the surprising death of Herod Agrippa I, another proud king who refused to honor God. When King Herod attired himself, sat on his throne, and received the worship of his subjects, immediately an angel of the Lord struck him down, and he died of a worm infestation.