What does Psalm 2:6 mean?

The unbelieving world thinks it can throw off God's truth and His will (Psalm 2:1–3). That will only earn a laugh, and wrath, from an all-powerful God (Psalm 2:4–5). The sovereign Creator of the universe will set His King—the Lord Jesus Christ, Israel's Messiah—on Mount Zion, His holy hill. The book of Psalms mentions Zion thirty-nine times. David, who wrote Psalm 2, conquered Zion when it was a city of the Jebusites (2 Samuel 5:7). Later, Zion referred to the temple area in Jerusalem and eventually it became synonymous with Jerusalem. God's "holy hill" refers to the temple mount.

Someday, Jesus, God's Anointed (Acts 4:23–28), will return to earth, subdue His enemies, and rule from Jerusalem (Isaiah 2:1–4; Malachi 3:1). In the angel Gabriel's address to Mary, he prophesied concerning Jesus: "He will be great and will be called the Son of the Most High. And the Lord God will give to him the throne of his father David, and he will reign over the house of Jacob forever, and of his kingdom there will be no end" (Luke 1:32–33). As surely as King David ruled from Jerusalem, so King Jesus will rule from Jerusalem!