What does Psalm 22:22 mean?

Having been rescued from death at the hands of his enemies, David plans to testify to God's goodness and praise Him in the assembly of Israel. This verse is quoted in Hebrews 2:12 and applied to Jesus. The writer of Hebrews leans on this verse's connection to the idea of confidence: that God will be praised because He will—ultimately—deliver the one who is praying.

Whereas David's congregation was composed of Israelites, Jesus' congregation is much broader. It is the church, and it includes both Jewish and Gentile believers. Ephesians 2:12 reminds the Ephesians that at one time Gentiles were "separated from Christ, alienated from the commonwealth of Israel and strangers to the covenants of promise." However, according to Ephesians 2:13, in Christ the Gentile believers are "brought near by the blood of Christ." As a result, in Christ, believing Jews and believing Gentiles are one new man (Ephesians 2:14–16). Colossians 1:18 calls this new union "the church."

David called his fellow Israelites, "my brothers," and at His open tomb Jesus instructed Mary to go to His brothers and tell them: "I am ascending to my Father and your Father, to my God and your God" (John 20:17).