What does Psalm 22:3 mean?

Despite the angst of what appears to be unanswered prayer (Psalm 22:1–2), this psalm takes an immediate step back into faith. Although David wonders why God did not answer him, he knows God is holy and is enthroned on the praises of His people. This is the essence of biblical faith: trust, based on prior experience, proven in the face of uncertainty or struggle (Hebrews 11:13–16).

Asking God, even in frustration, is not the same as defying Him. Other Old Testament passages, such as Habakkuk 1:2–4 and Psalm 44:23–24 express similar emotions. Instead of accusing God, David takes the high ground. He recognizes there is no unrighteousness with God. God never commits a wrong deed. Nor does He act capriciously. He is completely separate from evil and totally deserving of praise.

When Isaiah entered the temple after the death of Israel's King Uzziah, he caught a glimpse of Israel's eternal King, the Lord. He saw the Lord high and lifted up and heard the cherubim call, "Holy, holy, holy is the LORD of hosts; the whole earth is full of his glory!" (Isaiah 6:3). Psalm 99:2–3 calls upon everyone to praise the Lord who is holy. These verses say, "The LORD is great in Zion; he is exalted over all the peoples. Let them praise your great your great and awesome name! Holy is he!" When trouble strikes and the heavens are silent, instead of wallowing in self-pity, we should praise the Lord.