What does Psalm 83:5 mean?

Asaph continues to pray (Psalm 83:1) for God to act against enemies massing against Israel (Psalm 83:2–3). These opponents don't merely want to defeat God's chosen people. Rather, they want to annihilate them entirely, even erasing all memory of their existence (Psalm 83:4). In this case, Israel is not merely facing the normal threats of one nation competing with another. These enemy states are abnormally unified and driven by something more sinister. The enemies conspiring to attack are taking sides against God Himself.

In the New Testament era, an early opponent of the church was Saul of Tarsus, later known as Paul. He was "breathing threats and murder against the disciples of the Lord" (Acts 9:1). Saul was confronted by Christ while travelling to persecute believers. Saul was blinded by brilliant light and heard a voice saying, "Saul, Saul, why are you persecuting me…I am Jesus, whom you are persecuting" (Acts 9:3–5). Attacks on God's truth, and His people, are effectively assaults on the Lord.