What does Romans 1:29 mean?

In this passage, Paul has pointed out how mankind has no excuses for rejecting God. God has made Himself plain enough, in creation itself, that we ought to seek Him (Romans 1:18–20). Those who twist their minds in order to ignore that evidence simply become more and more foolish (Romans 1:21–22). This leads to general idolatry (Romans 1:23), and then to God's wrath. In particular, this wrath is expressed when God steps aside and lets us suffer the natural consequences of our sin. This begins with mankind's most pervasive temptation: sexuality (Romans 1:24–28).

Now Paul begins to list other ways in which humanity expresses our rebellion against God. God, for His part, has responded to our refusal to acknowledge Him as God by giving us up to indulge in all of these sins and to experience the natural, painful consequences of living outside of His direction for us. These sins are no different than those mentioned earlier, in that sense.

Humans who reject God become filled with all kinds of unrighteousness, evil, covetousness, and malice. Our desire to do wrong to get what we want rages unchecked. We are fully willing to hurt others to get what we want, leading us to be full of envy, murder, strife, deceitfulness, and maliciousness. We also gossip freely, an action the Bible always holds as a great evil.

Does this mean that every non-Christian person habitually does each and every one of these things? Clearly not. However, humanity as a whole is certainly guilty of all of these things and much more, because of the sin that is in each of us individually.