What does Romans 16:5 mean?
Paul concludes his instructions that his readers greet his longtime friends and co-workers Priscilla and Aquila with another greeting. He asks that they greet the church that meets in their house. By this, we know that Priscilla and Aquila were likely quite wealthy by the standards of their day, having a home large enough to host one of the house churches. They had done the same when they lived in Ephesus (1 Corinthians 16:9).Since Paul greets the church that meets at their house, this likely indicates that the church in Rome was large enough to gather at multiple locations.
Next Paul asks his readers to greet a man named Epaenetus. Paul describes him as the first convert to Christianity in Asia. The literal word used here is aparchē, sometimes translated as "firstfruits." Ephesus, where Priscilla and Aquila helped to establish a church, is a major city in the Roman province of Asia. Scholars speculate that Epaenetus was led to Christ by Priscilla and Aquila and then traveled to Rome with them to help with the ministry there.