What does Exodus 12:22 mean?
ESV: Take a bunch of hyssop and dip it in the blood that is in the basin, and touch the lintel and the two doorposts with the blood that is in the basin. None of you shall go out of the door of his house until the morning.
NIV: Take a bunch of hyssop, dip it into the blood in the basin and put some of the blood on the top and on both sides of the doorframe. None of you shall go out of the door of your house until morning.
NASB: And you shall take a bunch of hyssop and dip it in the blood which is in the basin, and apply some of the blood that is in the basin to the lintel and the two doorposts; and none of you shall go outside the door of his house until morning.
CSB: Take a cluster of hyssop, dip it in the blood that is in the basin, and brush the lintel and the two doorposts with some of the blood in the basin. None of you may go out the door of his house until morning.
NLT: Drain the blood into a basin. Then take a bundle of hyssop branches and dip it into the blood. Brush the hyssop across the top and sides of the doorframes of your houses. And no one may go out through the door until morning.
KJV: And ye shall take a bunch of hyssop, and dip it in the blood that is in the bason, and strike the lintel and the two side posts with the blood that is in the bason; and none of you shall go out at the door of his house until the morning.
NKJV: And you shall take a bunch of hyssop, dip it in the blood that is in the basin, and strike the lintel and the two doorposts with the blood that is in the basin. And none of you shall go out of the door of his house until morning.
Verse Commentary:
Prior to hearing from Moses (Exodus 12:21), Israel was given a command (Exodus 12:1–2) to prepare flawless lambs for sacrifice (Exodus 12:3–6). These were to be sacrificed at a certain time, and their blood applied to the doorways of each Israelite home (Exodus 12:7). This act symbolized the future ministry of Jesus Christ, who was also perfect, yet sacrificed to save others (1 Corinthians 5:6–8). His blood is the means by which those who trust in God can be saved from wrath (John 3:16–18, 36; 1 Peter 1:19). This passage offers more details.

The plant commonly called "hyssop" today may not be the same as the one described with the Hebrew word 'ēzob'. At the least, the plant would be similar, having a flowering head ideal for painting or dripping liquids. Commentators differ on whether the "basin" mentioned here is the bowl used to catch the lamb's blood, or a depression near the threshold used to catch rainwater and debris. Taking blood from this and applying it to the horizontal and vertical posts of the door created a visual expression of faith in God. Some interpreters believe that the motion of applying blood with hyssop would have created a bloody cross on the door (Colossians 1:19–20).

The family observing Passover was to remain inside for the entire night. God is bringing terrible wrath on Egypt (Exodus 11:4–6). Only those homes marked with lamb's blood will be spared (Exodus 12:13).
Verse Context:
Exodus 12:1–28 records the Lord's instructions for the first observation of Passover. The Israelites are to sacrifice lambs and prepare a specific set of foods. These must be eaten while dressed for travel. The lamb's blood is to be collected at the threshold of the door and then applied to the top and side posts. On that first Passover, God will kill the firstborn of Egypt (Exodus 11:4–6). Houses marked with the lamb's blood will be spared: God's judgment will "pass over" them without harm (Exodus 11:7). This event will establish a new start for Israel's yearly calendar. It is to be commemorated every year by using various symbolic elements. Future generations are to be carefully taught the meaning of these things.
Chapter Summary:
Israel is to realign their calendar to begin with the current month. They receive instructions to prepare a special meal. This includes sacrificing lambs and applying their blood to the doorway of each home. Following these instructions will cause God's wrath to "pass over" that house. Egypt's firstborn are killed and they demand Israel leave immediately. The people quickly gather their belongings and march out in a single massive group. These events are to be remembered with festivals to be celebrated for all time.
Chapter Context:
Moses was sent to lead Israel into freedom (Exodus 3:10). This meant announcing the Lord's supernatural judgments on Egypt (Exodus 3:19–21). After nine such disasters (Exodus 7:21; 8:6, 17, 24; 9:6, 10, 24; 10:14, 23), a tenth was promised (Exodus 4:21–23; 11:4–6). In this chapter, God provides instructions for Israel to both survive and commemorate this first Passover night. Egypt reels from the death of its firstborn and demands Israel leave that very night. More directions about the future are to come (Exodus 13). Then Pharaoh will once again change his mind and confront the Hebrews on the shores of the Red Sea (Exodus 14).
Book Summary:
The book of Exodus establishes God's covenant relationship with the full-fledged nation of Israel. The descendants of Abraham prosper after settling in Egypt, only to be enslaved by a fearful, hateful Egyptian Pharaoh. God appoints Moses to lead the people out of this bondage. Moses serves as God's spokesman, as the Lord brings plagues and judgments on Egypt, leading to the release of Israel.
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