What does Genesis 9:5 mean?
ESV: And for your lifeblood I will require a reckoning: from every beast I will require it and from man. From his fellow man I will require a reckoning for the life of man.
NIV: And for your lifeblood I will surely demand an accounting. I will demand an accounting from every animal. And from each human being, too, I will demand an accounting for the life of another human being.
NASB: I certainly will require your lifeblood; from every animal I will require it. And from every person, from every man as his brother I will require the life of a person.
CSB: And I will require a penalty for your lifeblood; I will require it from any animal and from any human; if someone murders a fellow human, I will require that person’s life.
NLT: And I will require the blood of anyone who takes another person’s life. If a wild animal kills a person, it must die. And anyone who murders a fellow human must die.
KJV: And surely your blood of your lives will I require; at the hand of every beast will I require it, and at the hand of man; at the hand of every man's brother will I require the life of man.
NKJV: Surely for your lifeblood I will demand a reckoning; from the hand of every beast I will require it, and from the hand of man. From the hand of every man’s brother I will require the life of man.
Verse Commentary:
Genesis 9 opens with God's blessings and commands to humanity as the world resets following the flood. In the previous verse, God commanded humans not to eat the blood of animals, calling the blood the creature's "life." This is one of the first moments in Scripture where blood, specifically, is tied to life. Later, through moments such as the first Passover (Exodus 12:1–7), and the sacrifices in the temple (Exodus 29:19–21; Leviticus 4:1–21), this reverence for blood will be magnified. The ultimate meaning of this symbol will be fulfilled in the sacrifice of Jesus Christ on the cross (John 1:29; 1 Corinthians 5:7).

This verse pivots from an animal's lifeblood to the shedding of the blood of humans. This is a new command for the way human communities should conduct themselves; it is a change from God's requirements for mankind before the flood. Specifically, God will require a reckoning—a dire accountability—when the lifeblood of a person is shed. God will require that reckoning whether the one who kills a person is a man or an animal. The next verse will reveal that reckoning to be the death of the one who kills any human being.

Following the first recorded murder in Scripture, God allowed Cain to live and, in fact, to thrive on the earth. With this new beginning after the flood, however, God will require death for the intentional, unjustified killing of another person.
Verse Context:
Genesis 9:1–17 continues God's interaction with Noah and his sons following the flood. First, God blesses them and gives them specific instructions about how to live in this remade world. God commands them to reproduce and fill the earth, among other things. Next, God establishes His unilateral covenant to never again end all life on earth with a flood, offering the rainbow as a sign of this promise.
Chapter Summary:
Chapter 9 describes God's interactions with Noah and his sons following the flood. First, God gives blessings and instructions, including the command to reproduce and fill the earth. Next, God makes a unilateral covenant with humanity and animals never to end all life with a flood again. He offers the rainbow as a sign of this promise. Finally, Noah prophesies about the future of his son's descendants after an awkward episode in which Ham talks to his brothers about seeing Noah passed out drunk and naked.
Chapter Context:
Chapters 6, 7, and 8 describe God's destruction of the world in a massive flood. Now, in Genesis 9, Scripture describes God's dealings with Noah and his sons following the flood. First, God blesses them and gives specific instructions, including the command to fill the earth. Next, God expands on His promise to never again end all life on earth a flood. Finally, Noah curses Ham and blesses Shem and Japheth after Ham tells his brothers about seeing Noah passed out drunk and naked. Chapters 10 and 11 will sketch out the history of mankind from Noah to Abraham.
Book Summary:
The book of Genesis establishes fundamental truths about God. Among these are His role as the Creator, His holiness, His hatred of sin, His love for mankind, and His willingness to provide for our redemption. We learn not only where mankind has come from, but why the world is in its present form. The book also presents the establishment of Israel, God's chosen people. Many of the principles given in other parts of Scripture depend on the basic ideas presented here in the book of Genesis. Within the framework of the Bible, Genesis explains the bare-bones history of the universe leading up to the captivity of Israel in Egypt, setting the stage for the book of Exodus.
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