What does Isaiah 28:21 mean?
ESV: For the Lord will rise up as on Mount Perazim; as in the Valley of Gibeon he will be roused; to do his deed — strange is his deed! and to work his work — alien is his work!
NIV: The Lord will rise up as he did at Mount Perazim, he will rouse himself as in the Valley of Gibeon— to do his work, his strange work, and perform his task, his alien task.
NASB: For the Lord will rise up as at Mount Perazim, He will be stirred up as in the Valley of Gibeon, To do His task, His unusual task, And to work His work, His extraordinary work.
CSB: For the Lord will rise up as he did at Mount Perazim. He will rise in wrath, as at the Valley of Gibeon, to do his work, his unexpected work, and to perform his task, his unfamiliar task.
NLT: The Lord will come as he did against the Philistines at Mount Perazim and against the Amorites at Gibeon. He will come to do a strange thing; he will come to do an unusual deed:
KJV: For the Lord shall rise up as in mount Perazim, he shall be wroth as in the valley of Gibeon, that he may do his work, his strange work; and bring to pass his act, his strange act.
NKJV: For the Lord will rise up as at Mount Perazim, He will be angry as in the Valley of Gibeon— That He may do His work, His awesome work, And bring to pass His act, His unusual act.
Verse Commentary:
Isaiah has confronted the leaders of Jerusalem for their foolish choice to make an alliance with Egypt (Isaiah 30:1–2) to save them from the Assyrians. He has described the arrangement as a covenant of death and taking refuge in a lie (Isaiah 28:15, 17–18). Not only will the Assyrians bring a hailstorm of destruction on Judah, but their attacks will also be the work of the Lord against His own people.

Isaiah says that the Lord will act as He did at Mount Perazim and in the Valley of Gibeon. Israelites would have known these stories. The Lord went before David to strike down the Philistines at Mount Perazim and destroyed the fleeing Amorites with large hailstones in the Valley of Gibeon (2 Samuel 5:17–25; Joshua 10:6–11). Judah should have known from their own history that the Lord could give them victory over their enemies. Instead, they looked for help from other nations.

Now, Isaiah says, the Lord is about to do a strange deed and perform an alien work. Instead of aiming His power against Israel's enemies, the Lord will work against His own people. He will send the Assyrian hailstorm against them for their faithlessness.
Verse Context:
Isaiah 28:14–29 describes God's warning to the leaders of Jerusalem and Judah. They are trusting what Isaiah calls "a covenant of death." They are sheltering from the coming Assyrian invasion under a "refuge of lies." Because they have not trusted the foundation the Lord has laid, He will work against His own people. Using a parable, Isaiah tells Judah's leaders to notice how the farmer follows the Lord's instructions to get the best crop.
Chapter Summary:
Samaria, the capital of Israel, also called Ephraim, is the beautiful crown on the head of the rich valley below. Her leaders are proud and drunk. The Lord will send the Assyrians to trample the crown and send the people into exile. Israel's religious leaders mock Isaiah, but they will hear the Lord's message from the Assyrians. Isaiah warns Jerusalem's leaders not to mock his warning to them from the Lord about the same fate. Their covenant with death will fail. The hailstorm of the Assyrians will beat them down. The Lord's counsel is wonderful.
Chapter Context:
Isaiah 28 begins a new section following the previous four chapters about Israel's glorious future with the Lord as her king. Now, though, the Lord is sending the Assyrians to judge His own people, first in Ephraim, which is Israel, and then in Judah. The beautiful capital city of Samaria will be trampled like a wilted wreath. Israel's religious leaders mock Isaiah but will hear the Lord's message from the Assyrians themselves. Isaiah warns Jerusalem's leaders not to scoff at his message. Despite Judah's agreements with other nations, the Lord will send the overwhelming scourge to wash away their refuge of lies. The next three chapters of Isaiah (29—31) predict siege and distress for Jerusalem but also promise that God will destroy Judah's enemies and bless them if they return to Him.
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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