What does Isaiah 37:22 mean?
ESV: this is the word that the Lord has spoken concerning him: "‘She despises you, she scorns you — the virgin daughter of Zion; she wags her head behind you — the daughter of Jerusalem.
NIV: this is the word the Lord has spoken against him: "Virgin Daughter Zion despises and mocks you. Daughter Jerusalem tosses her head as you flee.
NASB: this is the word that the Lord has spoken against him: 'She has shown contempt for you and derided you, The virgin daughter of Zion; The daughter of Jerusalem has shaken her head behind you!
CSB: this is the word the Lord has spoken against him: Virgin Daughter Zion despises you and scorns you; Daughter Jerusalem shakes her head behind your back.
NLT: the Lord has spoken this word against him: 'The virgin daughter of Zion despises you and laughs at you. The daughter of Jerusalem shakes her head in derision as you flee.
KJV: This is the word which the Lord hath spoken concerning him; The virgin, the daughter of Zion, hath despised thee, and laughed thee to scorn; the daughter of Jerusalem hath shaken her head at thee.
NKJV: this is the word which the Lord has spoken concerning him: “The virgin, the daughter of Zion, Has despised you, laughed you to scorn; The daughter of Jerusalem Has shaken her head behind your back!
Verse Commentary:
Hezekiah has physically laid out a letter from Assyria's king Sennacherib in the temple (Isaiah 37:14–15), He presents what the king of Assyria has said about the Lord (Isaiah 37:10–12) and asks God to save Judah (Isaiah 37:20). Here, the Lord begins to respond to Hezekiah's prayer through the faithful prophet Isaiah (Isaiah 37:21).

What follows (Isaiah 37:23–29) is the word of the Lord. This is direct prophecy—it is God's final word. What the Lord says here is what the Lord will surely do. The lyrical promise is addressed from the Lord to Sennacherib and Assyria. Although it is given in response to Hezekiah's prayer, the content is God's rebuttal of Sennacherib's boasting and mocking that against the Lord and His people.

God begins with a picture of a young girl mocking a much larger and more powerful attacker. An Assyrian messenger threatened Jerusalem in earshot of the city (Isaiah 36:12–15). Now, in ironic symbolism, a helpless child of Jerusalem openly mocks the Assyrian king. In a stunning reversal, the powerful invaders will be turned back (Isaiah 37:29).
Verse Context:
Isaiah 37:21–38 contains the Lord's response to Hezekiah's humble prayer (Isaiah 37:14–20). Through Isaiah, the Lord first addresses Sennacherib in a poem. He tells the most powerful man on earth at the time that God will turn him around and send him home. Next the Lord promises Hezekiah that Sennacherib will never even approach Jerusalem, let alone attack it. The remnant of Judah will survive and thrive. As the Assyrians plan to engage in a different battle, the Lord destroys nearly the entire army in a single night. Sennacherib goes home. He is later killed by his sons.
Chapter Summary:
Hezekiah is overcome with grief at news that Sennacherib has mocked the Lord and is coming to destroy Jerusalem. God reassures Hezekiah that the Asyrian king will return home to be killed there. Hezekiah prays in the temple, asking the Lord to defend His name and save Judah. Through Isaiah, the Lord reveals to Hezekiah that Jerusalem will not be touched. Assyria's army won't even have the chance to attack. Responding to their aggression and blasphemy, the "angel of the Lord" virtually wipes out the gigantic Assyrian army overnight. Sennacherib returns home and is later killed by his sons.
Chapter Context:
Isaiah 37 continues the narrative started in Isaiah 36. Assyrian messengers threaten to bring their enormous, nearby army to take Jerusalem. Hezekiah seeks God in response and is reassured that Jerusalem will not see so much as a single Assyrian arrow. The Lord promises to save the city and make the survivors prosper. The angel of the Lord kills an overwhelming number of Assyrian soldiers overnight. Sennacherib returns home and is eventually killed by his own sons. Hezekiah will then face a serious illness and be granted a brief reprieve by God (Isaiah 38).
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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