What does Isaiah 5:6 mean?
ESV: I will make it a waste; it shall not be pruned or hoed, and briers and thorns shall grow up; I will also command the clouds that they rain no rain upon it.
NIV: I will make it a wasteland, neither pruned nor cultivated, and briers and thorns will grow there. I will command the clouds not to rain on it."
NASB: I will lay it waste; It will not be pruned nor hoed, But briars and thorns will come up. I will also command the clouds not to rain on it.'
CSB: I will make it a wasteland. It will not be pruned or weeded; thorns and briers will grow up. I will also give orders to the clouds that rain should not fall on it.
NLT: I will make it a wild place where the vines are not pruned and the ground is not hoed, a place overgrown with briers and thorns. I will command the clouds to drop no rain on it.
KJV: And I will lay it waste: it shall not be pruned, nor digged; but there shall come up briers and thorns: I will also command the clouds that they rain no rain upon it.
NKJV: I will lay it waste; It shall not be pruned or dug, But there shall come up briers and thorns. I will also command the clouds That they rain no rain on it.”
Verse Commentary:
The owner of the failed vineyard is declaring his intention to destroy it. The vineyard's harvest is valueless and he is done with it. He will tear down the protective barrier that exists and leave the vineyard to the wild animals to decimate (Isaiah 5:5).

Now the owner adds that he will make no attempt to work it any longer. He wants it to become a wasteland. Instead of maintaining the vines, he will intentionally let thorns and weeds grow up and over the existing plants.

Next the farmer says he will tell the clouds not to rain on his vineyard. This reference would have been a strong indicator of exactly who was speaking. That was something only God can do. Did the original audience start to suspect just who this owner was at this point? Or did they just assume he was using hyperbole to express his bitter anger and disappointment?

The next verse (Isaiah 5:7) gives away exactly what Isaiah's song has been about all along, including who the vineyard is meant to represent.
Verse Context:
Isaiah 5:1–7 contains Isaiah's parable about his beloved about their vineyard. His beloved invests time and money to dig stones from the field, plant vines, build a watchtower, and make vats. He does all this work only to find the resulting grapes are sour and useless. The owner declares he will lay waste to the vineyard since the fruit is not good. Isaiah reveals that the vineyard is Israel and the owner is the Lord. He expected Judah to produce justice and integrity, but instead it has yielded trampling down of the weak and an ignoring of God's ways.
Chapter Summary:
Isaiah 5 begins with a parable about a farmer who builds a vineyard that produces sour grapes. The owner says he will lay waste to the vineyard. Isaiah reveals the owner to be the Lord and the vineyard to be Israel. Israel's bad fruit includes the greed of the wealthy and the hedonism of the people. They will go hungry and thirsty, into exile, and the grave. The Lord will be exalted for His righteousness. Isaiah pronounces woe on the sinners, the mockers, and the unjust rulers. The Lord will summon the nations to judge His people.
Chapter Context:
Early chapters (Isaiah 1—4) established a prophetic message given to the people of Israel. Isaiah 5 begins a new section with a parable about a vineyard that produces wild grapes despite all the work the owner has done. The vineyard is Israel, and the owner is the Lord. He will lay waste to the vineyard for the greed and drunkenness of the people. They will go into exile and the grave. The Lord will be exalted, but woe to those who embrace sin, and mock God's judgment. As well as those who take bribes against the poor. He has summoned the nations. Judgment is coming. The next chapter includes one of the Bible's most famous visions (Isaiah 6).
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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