What does Matthew 16:21 mean?
ESV: From that time Jesus began to show his disciples that he must go to Jerusalem and suffer many things from the elders and chief priests and scribes, and be killed, and on the third day be raised.
NIV: From that time on Jesus began to explain to his disciples that he must go to Jerusalem and suffer many things at the hands of the elders, the chief priests and the teachers of the law, and that he must be killed and on the third day be raised to life.
NASB: From that time Jesus began to point out to His disciples that it was necessary for Him to go to Jerusalem and to suffer many things from the elders, chief priests, and scribes, and to be killed, and to be raised up on the third day.
CSB: From then on Jesus began to point out to his disciples that it was necessary for him to go to Jerusalem and suffer many things from the elders, chief priests, and scribes, be killed, and be raised the third day.
NLT: From then on Jesus began to tell his disciples plainly that it was necessary for him to go to Jerusalem, and that he would suffer many terrible things at the hands of the elders, the leading priests, and the teachers of religious law. He would be killed, but on the third day he would be raised from the dead.
KJV: From that time forth began Jesus to shew unto his disciples, how that he must go unto Jerusalem, and suffer many things of the elders and chief priests and scribes, and be killed, and be raised again the third day.
NKJV: From that time Jesus began to show to His disciples that He must go to Jerusalem, and suffer many things from the elders and chief priests and scribes, and be killed, and be raised the third day.
Verse Commentary:
With this verse, a shift begins in Jesus' life and ministry, a change that will baffle His followers. To this point, Jesus has kept mainly to the region of Galilee in northern Israel, in addition to travelling to some Gentile regions around Galilee. He has avoided spending much time in Jerusalem, the religious and political heart of Israel. In fact, when He did come into conflict with Jewish religious leaders, He often left the area to keep things from escalating (Matthew 15:21).

Now, though, Jesus begins to show the disciples that time has ended. Instead, shockingly, Jesus begins to tell them that He must go to Jerusalem. He says to them clearly that He will suffer at the hands of the elders, chief priests, and scribes. In fact, He will be killed and then raised on the third day.

We know from the rest of the story that Jesus' mission was to die as a perfect, sinless sacrifice for the sins of humanity (John 12:32–34). This verse reveals that Jesus knew it also. He understood what must happen to Him for salvation to come, and He would not resist it (John 12:23–28). In their limited knowledge, Peter and the other disciples would resist that idea.
Verse Context:
Matthew 16:21–28 describes the disciples' reaction when Jesus reveals He must be killed by religious leaders and raised on the third day. Peter, recently praised for His faith (Matthew 16:17), chastises Jesus for saying such things. Jesus responds with a devastating rebuke of His own, saying "Get behind me, Satan!" Peter's insistence that Messiah could not be killed is based in his own assumptions, not truth. Christ warns that those who follow Him must be willing to give up all else in the world, and to take on hardship and persecution, as needed. He adds that some standing there will not die before seeing Him coming in His kingdom; this prediction is fulfilled in the next passage (Matthew 17:1–2).
Chapter Summary:
A group of Pharisees and Sadducees demand a miracle from Jesus, though He has already performed many. Jesus refuses and warns the disciples to beware of the teachings of these religious leaders. Jesus asks the disciples who the people say He is, as well as their own opinion. Peter says Jesus is the Christ, and is commended for that statement. Jesus begins to reveal that He must suffer and be killed before being raised on the third day. Peter's attempt to scold Jesus results in a devastating rebuke. Jesus then says all who would follow Him must take up crosses of self-denial.
Chapter Context:
Matthew 16 finds Jesus returned from the Gentile regions, only to be immediately confronted by another group of Jewish religious leaders. Yet again, these men prove they are insincere: no amount of evidence will ever be enough for them. After a dramatic discussion about Jesus' role as Messiah, Jesus indicates that those who would come after Him must take up their crosses and follow Him. His references to some seeing the Son of Man coming in His kingdom will be fulfilled at the beginning of chapter 17, in an event known as the transfiguration.
Book Summary:
The Gospel of Matthew clearly shows the influence of its writer's background, and his effort to reach a specific audience. Matthew was one of Jesus' twelve disciples, a Jewish man, and a former tax collector. This profession would have required literacy, and Matthew may have transcribed some of Jesus' words as they were spoken. This book is filled with references to the Old Testament, demonstrating to Israel that Jesus is the Promised One. Matthew also includes many references to coins, likely due to his former profession. Matthew records extensive accounts of Jesus' teaching, more than the other three Gospels.
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