What does Revelation 16:2 mean?
ESV: So the first angel went and poured out his bowl on the earth, and harmful and painful sores came upon the people who bore the mark of the beast and worshiped its image.
NIV: The first angel went and poured out his bowl on the land, and ugly, festering sores broke out on the people who had the mark of the beast and worshiped its image.
NASB: So the first angel went and poured out his bowl on the earth; and a harmful and painful sore afflicted the people who had the mark of the beast and who worshiped his image.
CSB: The first went and poured out his bowl on the earth, and severely painful sores broke out on the people who had the mark of the beast and who worshiped its image.
NLT: So the first angel left the Temple and poured out his bowl on the earth, and horrible, malignant sores broke out on everyone who had the mark of the beast and who worshiped his statue.
KJV: And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
NKJV: So the first went and poured out his bowl upon the earth, and a foul and loathsome sore came upon the men who had the mark of the beast and those who worshiped his image.
Verse Commentary:
When the first angel emptied his bowl onto the earth, grievous sores broke out on those who had the mark of the beast on the forehead or right hand (Revelation 13:16–18). These were unbelievers who worshiped the beast. The sores would certainly produce marks all over their bodies, just as they bore the mark of the beast. They had blasphemed God by practicing idolatry and would now pay the price. The Greek term here is helkos, which can refer to an ulcer or abscess—this is not a minor rash.

Centuries earlier the Philistines attempted to corrupt the Israelites' faith and faced stern judgment at God's heavy hand. He struck them with tumors (1 Samuel 5:6). When God struck Egypt with plagues, He caused boils to break out on the Egyptians' bodies (Exodus 9:8–11). Undoubtedly all business and social life will come to a grinding halt because of the severe pain humans experience from the sores. Because this bowl judgment targets the kingdom of the beast, we can conclude that the bowl judgments occur in the second half of the tribulation.

These same sores are mentioned during future plagues (Revelation 16:11), so these bowl judgments are not entirely separate from each other. At the very least, the effects of this judgment will not have ended before the next ones begin.
Verse Context:
Revelation 16:1–7 reports the beginning of the bowl judgments which were predicted in Revelation 15:5–8. The first and second judgments resemble the plague of boils and the plague of blood that God brought upon the Egyptians when Pharaoh refused to let the Hebrews leave Egypt (Exodus 7:19–21; 9:8–12). The third judgment turns the water sources into blood. The second and third judgments resemble the third trumpet judgment (Revelation 8:8), but their intensity is greater. A break occurs in 16:5–7 as an angel reflects on the first three bowl judgment and affirms that God is just to judge the wicked.
Chapter Summary:
This chapter explains the bowl judgments, which are the last and most severe of God's outpouring of wrath on earth. The first three bowls bring sores, seas of blood, and rivers of blood. After a declaration of God's justice come the next three bowl judgments, involving scorching sunlight, darkness, and a drying of the Euphrates to clear the way for an invading army. In the final, seventh bowl judgment, an earthquake tears Jerusalem into three parts, levels cities worldwide, and displaces islands and mountains. Hundred-pound hailstones fall, but unbelievers refuse to repent and instead continue to curse God.
Chapter Context:
Revelation 16 resumes the account of God's judgments on the wicked. It describes the bowl judgments, the third and final series of judgments. The seven seal judgments of Revelation 6:1–17 and 8:1 are the first series of judgments. The trumpet judgments of Revelation 8:1—9:21 and 11:15 are next. All of these judgments vent God's wrath and are recognized as the day of his wrath and the wrath of the Lamb (Revelation 6:17). Chapters 17 and 18 further describe the destruction caused by the judgments. Revelation 19 and 20 will describe the culmination of God's wrath and the final events of the end times.
Book Summary:
The word ''revelation'' means ''an unveiling or disclosure.'' This writing unveils future events such as the rapture, three series of judgments that will fall on the earth during the tribulation, the emergence of the Antichrist, the persecution of Israel and her amazing revival, as well as Jesus' second coming with His saints to the earth, the judgment of Satan and his followers, and finally, the eternal state. This content, combined with the original Greek term apokalypsis, is why we now refer to an end-of-the-world scenario as ''an apocalypse.''
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