What does Romans 1:21 mean?
ESV: For although they knew God, they did not honor him as God or give thanks to him, but they became futile in their thinking, and their foolish hearts were darkened.
NIV: For although they knew God, they neither glorified him as God nor gave thanks to him, but their thinking became futile and their foolish hearts were darkened.
NASB: For even though they knew God, they did not honor Him as God or give thanks, but they became futile in their reasonings, and their senseless hearts were darkened.
CSB: For though they knew God, they did not glorify him as God or show gratitude. Instead, their thinking became worthless, and their senseless hearts were darkened.
NLT: Yes, they knew God, but they wouldn’t worship him as God or even give him thanks. And they began to think up foolish ideas of what God was like. As a result, their minds became dark and confused.
KJV: Because that, when they knew God, they glorified him not as God, neither were thankful; but became vain in their imaginations, and their foolish heart was darkened.
NKJV: because, although they knew God, they did not glorify Him as God, nor were thankful, but became futile in their thoughts, and their foolish hearts were darkened.
Verse Commentary:
This section began with Paul's declaration that God's wrath is revealed against human unrighteousness. In particular, this wrath comes because God has made Himself plain enough to mankind that nobody has an excuse for ignoring Him. We may choose not to seek Him (Matthew 7:7–8), but we cannot pretend that we did not have enough evidence (Romans 1:18–20). The rest of the section will explain why that is and what God is prepared to do about it.

"Why" humanity is able to deny a God who is so obvious starts with the fact that human beings refuse to see who God is. We make a willful choice to ignore His hallmarks in the creation that surrounds us every day. In other words, we reject Him first as Creator.

Now we see that rejecting God as creator leads to a refusal to honor or give thanks to God. After all, why honor a God who did not make the world? And if God is not the creator, why would we assume that He is the provider of all we need? Why give thanks to God for what we believe we have developed and acquired for ourselves?

If we do not understand God as the creator and provider who must be worshiped, we cannot arrive at a right understanding of how the universe works. Our thinking about everything is futile, worthless from the square one. Futile thinking leads to wrong conclusions and, eventually, to darkened hearts. Everything we end up believing is based on wrong assumptions about the universe and our place in it.

For example, many will decide that a universe which God did not create and does not sustain is without meaning or purpose. That conclusion often leads to hopelessness and nihilism: the belief that life is meaningless.
Verse Context:
Romans 1:18–32 describes why God rightfully condemns humanity and some of what He has done about it. Humanity's fall is pictured as a downward progression. It starts with rejecting God as creator, refusing to see what can be known about Him by what He has made. We also reject that He is our provider and stop giving Him thanks. We worship His creation instead of Him. Finally, God acts by giving us over to the unchecked expression of our corrupt sexual desires and all other kinds of sin. In part, He expresses His wrath by giving us what we want and condemning us to suffer the painful consequences.
Chapter Summary:
Romans 1 introduces Paul and his purpose in writing this letter to the Christians in Rome. As servant and apostle of Jesus, Paul's mission in life is to preach the gospel of Jesus to all people groups, both Jews and Gentiles. He hopes to do so in Rome soon. Paul is not ashamed of the gospel. It is God's power for the salvation of all people by faith in Christ. We need to be saved because God is angry with us. Because of our sin, humanity has rejected Him as creator and provider. We worship created things, instead. In response, God has given us over to indulge in all kinds of sinful practices that lead to misery now and His angry judgment later.
Chapter Context:
Romans 1 begins with Paul's introduction of himself and his mission to preach the gospel of Jesus Christ. After telling the Christians in Rome that he is eager to come see them and preach the gospel there, Paul declares that the gospel is God's power to save everyone who believes in Jesus. We need to be saved, because our sin has earned God's wrath. As a whole, humanity has rejected God as creator and provider. We worship creation instead of Him. In response, He has given us over to the full indulgence of our sinful desires. We are guilty and deserve His judgment.
Book Summary:
The book of Romans is the New Testament's longest, most structured, and most detailed description of Christian theology. Paul lays out the core of the gospel message: salvation by grace alone through faith alone. His intent is to explain the good news of Jesus Christ in accurate and clear terms. As part of this effort, Paul addresses the conflicts between law and grace, between Jews and Gentiles, and between sin and righteousness. As is common in his writing, Paul closes out his letter with a series of practical applications.
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