What does Genesis 21:12 mean?
ESV: But God said to Abraham, “Be not displeased because of the boy and because of your slave woman. Whatever Sarah says to you, do as she tells you, for through Isaac shall your offspring be named.
NIV: But God said to him, 'Do not be so distressed about the boy and your slave woman. Listen to whatever Sarah tells you, because it is through Isaac that your offspring will be reckoned.
NASB: But God said to Abraham, 'Do not be distressed because of the boy and your slave woman; whatever Sarah tells you, listen to her, for through Isaac your descendants shall be named.
CSB: But God said to Abraham, "Do not be distressed about the boy and about your slave. Whatever Sarah says to you, listen to her, because your offspring will be traced through Isaac,
NLT: But God told Abraham, 'Do not be upset over the boy and your servant. Do whatever Sarah tells you, for Isaac is the son through whom your descendants will be counted.
KJV: And God said unto Abraham, Let it not be grievous in thy sight because of the lad, and because of thy bondwoman; in all that Sarah hath said unto thee, hearken unto her voice; for in Isaac shall thy seed be called.
NKJV: But God said to Abraham, “Do not let it be displeasing in your sight because of the lad or because of your bondwoman. Whatever Sarah has said to you, listen to her voice; for in Isaac your seed shall be called.
Verse Commentary:
Abraham was very displeased about Sarah's angry demand that Hagar and Ishmael be cast out of their household. The language may indicate that he became explosively angry. He clearly loved Ishmael, who was born to Sarah's servant Hagar at Sarah's own urging. This was not the first time Sarah reacted to Hagar with anger and bitterness (Genesis 16:4–6). Abraham is understandably concerned: he does not want to see his teenaged son die from being cast out.

Now God speaks to Abraham and tells him not to be displeased. In fact, He tells Abraham to do whatever Sarah tells him to do. God agrees with Sarah's point about Isaac and his inheritance, restating what He said to Abraham in Genesis 17:21: Abraham's name will pass to Isaac, not Ishmael.

Though God will assure Abraham again in the following verse that Hagar and Ishmael will be blessed, it still seems harsh for Abraham to cast them out in into the wilderness. It doesn't seem that either the mother or the boy have done anything to deserve such treatment. The context, however, is clear that the Lord intended to take the responsibility for caring for Hagar and Ishmael Himself. He would not abandon them.

As painful as it was for Abraham, God wanted Abraham to end his role in Ishmael's life for the sake of the covenant and Israel's future.
Verse Context:
Genesis 21:8–21 describes the painful departure of Hagar and Ishmael from Abraham's life. Now that Isaac is born, Sarah furiously demands that Abraham cast them out. He is greatly displeased, but is told by God that Ishmael will be protected and blessed. So Abraham obeys the Lord and sends them into the wilderness. God steps in and saves the mother and child. He renews his promise to make Ishmael a great nation in his own right. Ishmael grows up in the wilderness, eventually marrying an Egyptian woman.
Chapter Summary:
The Lord did as He had promised. Sarah, now 90 years old, gives birth to Isaac, the long-awaited child. Her joy sours, though, over a fear that Isaac might have to share an inheritance with Ishmael. In obedience to the Lord, who promises to safeguard Ishmael, Abraham sends him and his mother, Hagar, into the wilderness. God rescues them and renews His promise to make Ishmael a great nation in his own right. Meanwhile, Abimelech, king of Gerar, approaches Abraham to make a permanent treaty between them and their descendants. The agreement includes Abraham's possession of a well, at a place which will become known as Beersheba.
Chapter Context:
In the prior chapter, Abraham managed to get Sarah back from Abimelech, following his own deception and God's intervention. Here, Abraham and Sarah finally conceive a natural child. Isaac, the long-awaited child of the promise, is born. In obedience to God, Abraham sends Hagar and Ishmael away. Abimelech approaches Abraham to make a treaty, giving Abraham a permanent home in a place that becomes known as Beersheba. In the following chapter, God will test Abraham's faith and obedience, in one of Scripture's ultimate examples of trust.
Book Summary:
The book of Genesis establishes fundamental truths about God. Among these are His role as the Creator, His holiness, His hatred of sin, His love for mankind, and His willingness to provide for our redemption. We learn not only where mankind has come from, but why the world is in its present form. The book also presents the establishment of Israel, God's chosen people. Many of the principles given in other parts of Scripture depend on the basic ideas presented here in the book of Genesis. Within the framework of the Bible, Genesis explains the bare-bones history of the universe leading up to the captivity of Israel in Egypt, setting the stage for the book of Exodus.
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