What does Genesis 21:4 mean?
ESV: And Abraham circumcised his son Isaac when he was eight days old, as God had commanded him.
NIV: When his son Isaac was eight days old, Abraham circumcised him, as God commanded him.
NASB: Then Abraham circumcised his son Isaac when he was eight days old, as God had commanded him.
CSB: When his son Isaac was eight days old, Abraham circumcised him, as God had commanded him.
NLT: Eight days after Isaac was born, Abraham circumcised him as God had commanded.
KJV: And Abraham circumcised his son Isaac being eight days old, as God had commanded him.
NKJV: Then Abraham circumcised his son Isaac when he was eight days old, as God had commanded him.
Verse Commentary:
On the very same day when God had changed Abram's name to Abraham, and Sarai's name to Sarah, He told Abraham that Sarah would have a son within a year and they would call him Isaac. Abraham had laughed (Genesis 17:15–17). On that day, God had also commanded Abraham to be circumcised, along with every male in his household, and to circumcise all future male children born to his household at eight days old (Genesis 17:10–13).

The act of circumcision involves removing the foreskin from the penis, cutting in a circle around the organ. This ritual is deeply symbolic, echoing God's sovereignty over fertility and children, the uniqueness of His people, and the permanence of His influence. God would continue the requirement for circumcision in the laws given to Israel through Moses (Leviticus 12:3).

Now Abraham obeys that command with this promised son Isaac, circumcising him on the eighth day of his life.
Verse Context:
Genesis 20:1–7 describes the moment Abraham and Sarah have been waiting on for many, many years. Ever since leaving their home to begin to wander in the land of Canaan, this is a promise they have wished to see fulfilled. God had promised to make Abraham a great nation, by giving him and Sarah a naturally-born son. Finally, their first child together is born. Isaac's name means ''laughter,'' and Sarah expresses her joy at his birth. God has done the unbelievable. He has made laughter for her.
Chapter Summary:
The Lord did as He had promised. Sarah, now 90 years old, gives birth to Isaac, the long-awaited child. Her joy sours, though, over a fear that Isaac might have to share an inheritance with Ishmael. In obedience to the Lord, who promises to safeguard Ishmael, Abraham sends him and his mother, Hagar, into the wilderness. God rescues them and renews His promise to make Ishmael a great nation in his own right. Meanwhile, Abimelech, king of Gerar, approaches Abraham to make a permanent treaty between them and their descendants. The agreement includes Abraham's possession of a well, at a place which will become known as Beersheba.
Chapter Context:
In the prior chapter, Abraham managed to get Sarah back from Abimelech, following his own deception and God's intervention. Here, Abraham and Sarah finally conceive a natural child. Isaac, the long-awaited child of the promise, is born. In obedience to God, Abraham sends Hagar and Ishmael away. Abimelech approaches Abraham to make a treaty, giving Abraham a permanent home in a place that becomes known as Beersheba. In the following chapter, God will test Abraham's faith and obedience, in one of Scripture's ultimate examples of trust.
Book Summary:
The book of Genesis establishes fundamental truths about God. Among these are His role as the Creator, His holiness, His hatred of sin, His love for mankind, and His willingness to provide for our redemption. We learn not only where mankind has come from, but why the world is in its present form. The book also presents the establishment of Israel, God's chosen people. Many of the principles given in other parts of Scripture depend on the basic ideas presented here in the book of Genesis. Within the framework of the Bible, Genesis explains the bare-bones history of the universe leading up to the captivity of Israel in Egypt, setting the stage for the book of Exodus.
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