What does Genesis 25:18 mean?
ESV: They settled from Havilah to Shur, which is opposite Egypt in the direction of Assyria. He settled over against all his kinsmen.
NIV: His descendants settled in the area from Havilah to Shur, near the eastern border of Egypt, as you go toward Ashur. And they lived in hostility toward all the tribes related to them.
NASB: They settled from Havilah to Shur which is east of Egypt going toward Assyria; he settled in defiance of all his relatives.
CSB: And they settled from Havilah to Shur, which is opposite Egypt as you go toward Asshur. He stayed near all his relatives.
NLT: Ishmael’s descendants occupied the region from Havilah to Shur, which is east of Egypt in the direction of Asshur. There they lived in open hostility toward all their relatives.
KJV: And they dwelt from Havilah unto Shur, that is before Egypt, as thou goest toward Assyria: and he died in the presence of all his brethren.
NKJV: (They dwelt from Havilah as far as Shur, which is east of Egypt as you go toward Assyria.) He died in the presence of all his brethren.
Verse Commentary:
Ishmael's twelve sons, listed in the previous verses, became twelve tribes, establishing villages or wandering camps named for each of them. These twelve groups settled primarily in the region to the east of the land that would become Israel. This fulfills a promise God made to Hagar, Ishmael's mother. Before they were evicted from Abraham's family (Genesis 21:8–14), God vowed to make Ishmael and his offspring successful (Genesis 16:10–12).

That prophecy came with more than just an assurance of success, however. In Genesis 16:12, God had also prophesied that Ishmael would become a wild donkey of a man who would dwell over and against all his kinsmen. Now we see that is what became of Ishmael's sons, perhaps suggesting their later conflicted relationship with Israel.
Verse Context:
Genesis 25:1–18 adds details before describing the deaths of Abraham and then Ishmael. Abraham has taken another wife, other than Sarah, and has six sons with her. He gives them gifts but sends them all away to the east. Isaac will be his sole true heir. Still, when Abraham dies and is buried at the age of 175, Ishmael joins Isaac for the funeral. Ishmael's 12 sons are listed, along with a description of the region their tribes settled in. Finally, Ishmael dies, as well, at the age of 137.
Chapter Summary:
Genesis 25 is packed with information. Abraham marries another wife, most likely before Sarah died, and has six sons with her. Abraham dies at the age of 175 and is buried by both Isaac and Ishmael at the family-owned cave where Sarah was buried. Ishmael's 12 sons are listed, along with the region their tribes settled in, to the east of what would later become Israel. And, finally, God grants Isaac's prayer for Rebekah to become pregnant by giving the couple twins: the feuding Jacob and Esau.
Chapter Context:
The previous chapter tells the story of how Abraham's servant found a wife for Isaac from among Abraham's people. This chapter rushes to fill in the details of the end of Abraham's life before beginning the story of Isaac's years as patriarch. Abraham marries another woman and has six sons with her, eventually sending them all away from Isaac. Abraham dies and is buried with Sarah. Ishmael's 12 sons are listed, and then his death is recorded, as well. Finally, Isaac's twin boys are born in response to his prayer to the Lord.
Book Summary:
The book of Genesis establishes fundamental truths about God. Among these are His role as the Creator, His holiness, His hatred of sin, His love for mankind, and His willingness to provide for our redemption. We learn not only where mankind has come from, but why the world is in its present form. The book also presents the establishment of Israel, God's chosen people. Many of the principles given in other parts of Scripture depend on the basic ideas presented here in the book of Genesis. Within the framework of the Bible, Genesis explains the bare-bones history of the universe leading up to the captivity of Israel in Egypt, setting the stage for the book of Exodus.
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