What does Isaiah 19:21 mean?
ESV: And the LORD will make himself known to the Egyptians, and the Egyptians will know the LORD in that day and worship with sacrifice and offering, and they will make vows to the LORD and perform them.
NIV: So the LORD will make himself known to the Egyptians, and in that day they will acknowledge the LORD. They will worship with sacrifices and grain offerings; they will make vows to the LORD and keep them.
NASB: So the Lord will make Himself known to Egypt, and the Egyptians will know the Lord on that day. They will even worship with sacrifice and offering, and will make a vow to the Lord and perform it.
CSB: The Lord will make himself known to Egypt, and Egypt will know the Lord on that day. They will offer sacrifices and offerings; they will make vows to the Lord and fulfill them.
NLT: The Lord will make himself known to the Egyptians. Yes, they will know the Lord and will give their sacrifices and offerings to him. They will make a vow to the Lord and will keep it.
KJV: And the LORD shall be known to Egypt, and the Egyptians shall know the LORD in that day, and shall do sacrifice and oblation; yea, they shall vow a vow unto the LORD, and perform it.
NKJV: Then the Lord will be known to Egypt, and the Egyptians will know the Lord in that day, and will make sacrifice and offering; yes, they will make a vow to the Lord and perform it.
Verse Commentary:
Isaiah continues by describing Egypt's transformation. They are the object of the Lord's judgment in Isaiah's near future, and then a people in genuine relationship with the Lord in the distant future. Not only will Egypt be rescued from her oppressors by the Lord, but they will also come to know Him as their Lord and the source of their security (Isaiah 19:18–20).

Egypt had "known" the God of the Israelites before, but only in the shallowest or most negative sense of that word. They understood that Israel's God was the one sending plagues and suffering upon their people during the time of Exodus (Exodus 7:5; 9:28). Now they will know the Lord in the most positive context by being in a worship relationship with Him (Psalm 100:3). Egypt's worship will include sacrifices and offerings to the Lord. This worship will also include making and keeping vows to God.

In Israel's worship, vows were made and performed as an expression of thanks to the Lord (Psalm 22:26). These vows were "paid off" when the Lord answered prayer in a specific way (1 Samuel 1:11). The fact that the Egyptians will also take part in such worship practices shows just how deeply they will participate in the worship of Israel's God.
Verse Context:
Isaiah 19:16–25 presents a sudden change in tone. It follows an oracle of judgment against Egypt with a promise of future blessing from the Lord. This seems to take place during the kingdom of the Messiah on earth (Isaiah 2:1–5; Revelation 20:1–4). Egypt will fear the Lord and repent and worship Him alone. God will bless them, rescue them, and call them His people. Egypt will become peaceful allies with Assyria, and the Assyrians will worship the Lord, as well. Together, Egypt, Assyria, and Israel will bless the earth and be blessed by the Lord.
Chapter Summary:
Isaiah's oracle describes the Lord's coming judgment on Egypt. The idols will fear when God arrives, and the people will turn on each other. A fierce king will conquer them. The Nile River will dry up, leaving many destitute. The advisors serving Egypt's leaders will be revealed as confused fools. Far in the future, Egypt will recognize Israel's God and repent, turning to worship the Lord. Assyria will join in that worship, blessing the earth along with Egypt and Israel.
Chapter Context:
Isaiah 19 introduces the next oracle against the nations of the earth. The Lord has been showing His people not to put their trust and hope in the foreign nations or their gods. They are to trust in Him alone to save them. The Lord's arrival in Egypt reveals the worthlessness of idols and spiritists. The terrified people will turn on each other. They will become destitute when the Nile dries up and the wise are shown to be foolish. In the far future, Egypt will worship the Lord and be blessed by Him.
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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