What does Isaiah 21:3 mean?
ESV: Therefore my loins are filled with anguish; pangs have seized me, like the pangs of a woman in labor; I am bowed down so that I cannot hear; I am dismayed so that I cannot see.
NIV: At this my body is racked with pain, pangs seize me, like those of a woman in labor; I am staggered by what I hear, I am bewildered by what I see.
NASB: For this reason my loins are full of anguish; Pains have seized me like the pains of a woman in labor. I am so bewildered I cannot hear, so terrified I cannot see.
CSB: Therefore I am filled with anguish. Pain grips me, like the pain of a woman in labor. I am too perplexed to hear, too dismayed to see.
NLT: My stomach aches and burns with pain. Sharp pangs of anguish are upon me, like those of a woman in labor. I grow faint when I hear what God is planning; I am too afraid to look.
KJV: Therefore are my loins filled with pain: pangs have taken hold upon me, as the pangs of a woman that travaileth: I was bowed down at the hearing of it; I was dismayed at the seeing of it.
NKJV: Therefore my loins are filled with pain; Pangs have taken hold of me, like the pangs of a woman in labor. I was distressed when I heard it; I was dismayed when I saw it.
Verse Commentary:
Isaiah's vision from the Lord terrified him to the point of physical pain. He saw dreadful destruction coming for Babylon. This vision deeply wounded him thinking of those who would suffer. This agony was almost more than he could bear. He writes that his body was wracked with pain. Cramps take hold of him like the contractions of a woman going through labor. It would be fair to picture him as doubled over in misery. This vision has so wrecked him that he cannot see or hear any more of it. It is just too painful for him.

Why was Isaiah so moved by this vision of destruction? This isn't the first vision mentioned in his book, why is this one so much more tragic? We don't know the answer to that question. But what is clear is that what he saw coming for the people of Babylon must have been truly horrific. By all accounts, Sennacherib, who destroyed Babylon in 689 BC, was especially cruel to those he defeated.
Verse Context:
Chapter 21:1–10 contains Isaiah's prophecy against Babylon. God sends Isaiah a fierce vision which causes him great physical suffering and emotional terror. His heart falters, and his body trembles at what he witnesses. Isaiah calls the leaders to prepare for battle. He obeys the Lord's call for a watchman, taking his post on the tower until the riders come. When they arrive, the prophet announces that Babylon is fallen and her gods have all been smashed.
Chapter Summary:
This chapter delivers oracles against three people groups. Isaiah is terrified to the point of physical pain by the vision he sees. God reveals the terrible things coming for Babylon. Isaiah answers the Lord's call to be a watchman. When he sees the arrival of riders approaching the city, he announces that Babylon has fallen. The oracle against Dumah presents a question from an Edomite with an unsatisfying answer. The oracle against Arabia pictures starving refugees that must be fed and declares that the warriors of Kedar will be nearly wiped out within a year.
Chapter Context:
Earlier chapters included prophecies about nations such as Aram, Egypt, and Cush. Chapter 21 presents three more oracles against Israel's regional neighbors. What Isaiah sees is so horrific that he suffers intense physical pain just from watching. He answers the call to be a watchman, eventually announcing that Babylon has fallen. An oracle against Dumah provides no real answer to the question of how long the night of suffering will continue for Edom. Arabia, too, will suffer at the hand of powerful regional forces. Next is a prophecy about Jerusalem.
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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