What does Isaiah 8:21 mean?
ESV: They will pass through the land, greatly distressed and hungry. And when they are hungry, they will be enraged and will speak contemptuously against their king and their God, and turn their faces upward.
NIV: Distressed and hungry, they will roam through the land; when they are famished, they will become enraged and, looking upward, will curse their king and their God.
NASB: They will pass through the land dejected and hungry, and it will turn out that when they are hungry, they will become enraged and curse their king and their God as they face upward.
CSB: They will wander through the land, dejected and hungry. When they are famished, they will become enraged, and, looking upward, will curse their king and their God.
NLT: They will go from one place to another, weary and hungry. And because they are hungry, they will rage and curse their king and their God. They will look up to heaven
KJV: And they shall pass through it, hardly bestead and hungry: and it shall come to pass, that when they shall be hungry, they shall fret themselves, and curse their king and their God, and look upward.
NKJV: They will pass through it hard-pressed and hungry; and it shall happen, when they are hungry, that they will be enraged and curse their king and their God, and look upward.
Verse Commentary:
Isaiah has described those who refuse to receive God' revealed truth as living in darkness. The day never dawns for them (Isaiah 8:20). They live in this darkness and some choose to seek answers from the dead instead of from the Lord (Isaiah 8:19). This practice—called divination or necromancy—was explicitly forbidden by God (Leviticus 19:31).

Now Isaiah describes them as "hungry," perhaps meaning that they are devoid of meaning. They pass through the land full of rage because of this lack. In their anger, they lash out with their words against the king and against their God. The image evoked here is a people shaking their fists at the Lord. They remain empty and unsatisfied. They dwell in darkness because they refused the light God offered to them through His revelation and the law.

It's also possible that Isaiah is describing the coming of the Lord's judgment when they will not have enough to eat. In their hunger, they will reject the Lord instead of turning to Him in humility and submission for help in their time of great need.
Verse Context:
Isaiah 8:11–22 follows the prophecy about the coming destruction from the Assyrians. It includes a strong warning from the Lord to Isaiah to not follow the sins of the rest of Judah. He must not fear real or imagined threats. Instead, Isaiah must honor God and find safety in Him. The people will reject God, leading to ruin, and being taken away. Isaiah declares he will wait on the Lord and his family will be a sign that God has not abandoned those who trust Him. Those who reject God's Word, however, will remain in darkness.
Chapter Summary:
Isaiah 8 begins with the Lord telling Isaiah to write a name on a large sign. Then Isaiah conceives a son, with a woman referred to as the "prophetess," likely his wife. The son is given the name on the sign. Before the son can speak, Judah's enemies will be wiped out by Assyria. Assyria will then bring destruction on Judah. Isaiah must not live in fear and dread as the people do. They will stumble over the stone of the Lord instead of trusting in Him. Isaiah will continue to hope in the Lord. Those who reject God's truth will live in darkness.
Chapter Context:
The prior chapter included a famous prophecy regarding the virgin birth of Jesus. Isaiah 8 continues to prophesy about the coming destruction of Judah's current enemies: Syria and Israel. Isaiah has a son whose name he has written on a sign. Before that son is old enough to talk, Assyria will destroy Judah's enemies and then bring destruction into Judah. The Lord warns Isaiah to honor God, not live in fear. The people will reject God as their foundation, falling into further sin. But Isaiah declares that he and his family will continue to point toward God's faithfulness. Those who reject God's revelation will live in and frustration and despair. This sets up additional prophecies which connect to the ministry of Christ.
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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