What does Isaiah 9:21 mean?
ESV: Manasseh devours Ephraim, and Ephraim devours Manasseh; together they are against Judah. For all this his anger has not turned away, and his hand is stretched out still.
NIV: Manasseh will feed on Ephraim, and Ephraim on Manasseh; together they will turn against Judah. Yet for all this, his anger is not turned away, his hand is still upraised.
NASB: Manasseh devours Ephraim, and Ephraim Manasseh, And together they are against Judah. In spite of all this, His anger does not turn away And His hand is still stretched out.
CSB: Manasseh eats Ephraim, and Ephraim, Manasseh; together, both are against Judah. In all this, his anger has not turned away, and his hand is still raised to strike.
NLT: Manasseh will feed on Ephraim, Ephraim will feed on Manasseh, and both will devour Judah. But even then the Lord’s anger will not be satisfied. His fist is still poised to strike.
KJV: Manasseh, Ephraim; and Ephraim, Manasseh: and they together shall be against Judah. For all this his anger is not turned away, but his hand is stretched out still.
NKJV: Manasseh shall devour Ephraim, and Ephraim Manasseh; Together they shall be against Judah. For all this His anger is not turned away, But His hand is stretched out still.
Verse Commentary:
Wickedness is like a fire that grows and consumes all the fuel it can reach (Isaiah 9:1–19). It is also like cannibalism in that we devour each other and even ourselves to feed the insatiable appetite for more sin (Isaiah 9:20; Galatians 5:15).

Now Isaiah describes what this unchecked wickedness has done to Israel. Manasseh and Ephraim devour each other. These were two of the largest and most prominent tribes in Israel. Both were descended from two sons of Joseph. This heightened their connection as brothers among tribes of brothers. When sin goes unstopped, unrestrained, even brothers will destroy each other. That's what sin does (Psalm 50:19–20).

Isaiah's references to these conflicts between tribes in northern Israel reflects the endless coups and battles for the control of the throne of ancient Israel. United, the nation of Israel stood against their brothers in the nation of Judah. Inside the borders, however, the battles between the tribes could be just as intense. Each man, family, and tribe sought only to serve themselves.

Isaiah ends the chapter by repeating, for the third time, that despite all this judgment on Israel, the Lord's anger was still not satisfied. Without repentance, the Lord's hand remained outstretched and ready to strike His people again.
Verse Context:
Isaiah 9:8–21 returns to describing the judgment coming upon Israel in Isaiah's time. Despite the arrogance of the people, the enemies of their allies will devour them. When the people do not repent, the Lord will wipe out their leaders. He will have no compassion for the sinful people in every level of society. Wickedness burns through the people like a wildfire, turning human lives into fuel. Sinfulness causes people to devour each other and even themselves in trying to satisfy sin's appetite. The Lord will judge Israel for all of it.
Chapter Summary:
Isaiah 9 begins prophecy about a future when darkness will be lifted from Israel. The nation will be free, prosperous, and at permanent peace. This will happen because God will send a child who will become a king on David's throne. More than a man, this king will be called Mighty God and Prince of Peace and will rule forever. In Isaiah's day, though, God's judgment will soon fall on Israel. He will wipe out their leaders. Wickedness burns through the nation like fire.
Chapter Context:
Isaiah 9 begins with what may be the conclusion of the previous chapter. Isaiah 8 ended with the description of the darkness experienced by those in Israel who reject the Lord. The prophet describes a day in Israel's far future when the gloom will lift and glory will return. A child will become king of Israel, but He will also be the Everlasting Father who will rule forever. However, In Isaiah's time, the Lord will judge Israel with destruction from other nations. The following chapter pronounces disaster for the people who persist in sin.
Book Summary:
Isaiah is among the most important prophetic books in the entire Bible. The first segment details God's impending judgment against ancient peoples for sin and idolatry (Isaiah 1—35). The second part of Isaiah briefly explains a failed assault on Jerusalem during the rule of Hezekiah (Isaiah 36—39). The final chapters predict Israel's rescue from Babylonian captivity (Isaiah 40—48), the promised Messiah (Isaiah 49—57), and the final glory of Jerusalem and God's people (Isaiah 58—66).
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