What does Genesis 25:18 mean?
Ishmael's twelve sons, listed in the previous verses, became twelve tribes, establishing villages or wandering camps named for each of them. These twelve groups settled primarily in the region to the east of the land that would become Israel. This fulfills a promise God made to Hagar, Ishmael's mother. Before they were evicted from Abraham's family (Genesis 21:8–14), God vowed to make Ishmael and his offspring successful (Genesis 16:10–12).That prophecy came with more than just an assurance of success, however. In Genesis 16:12, God had also prophesied that Ishmael would become a wild donkey of a man who would dwell over and against all his kinsmen. Now we see that is what became of Ishmael's sons, perhaps suggesting their later conflicted relationship with Israel.