What does Isaiah 13:20 mean?
Isaiah has been describing the destruction that will fall on the proud city-state of Babylon when the "day of the Lord" comes for them (Isaiah 13:6; Ezekiel 30:3; Joel 1:15). The city will be attacked, invaded, and the people utterly wiped out. The destruction will be well-earned, but nevertheless cruel, and without mercy (Isaiah 13:19).This prophecy adds that the city will not be inhabited for all generations. Some scholars suggest that the language here should be read as "many generations." It either case, the city as it was known would no longer exist as a place to live. The dream of Babylon would be dramatically and traumatically ended by the hand of the Lord. The false glory and power of the city would be snuffed out forever.
Isaiah adds that even the wandering nomads, described as "Arabs" in some translations, will not settle in the ruins of Babylon. Shepherds will also not shelter their flocks there for the night. The city will eventually become unfit for human occupation of any kind. Instead, this former showcase for human glory will return to a place for the wild glory of God's animal creation to dwell in (Isaiah 13:21–22).